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Montelukast can cause different side effects at varying degrees such as gastrointestinal disturbances, hypersensitivity or allergic reactions, sleep disorders, stomach upset, diarrhea, cough, dizziness, headache, nausea, vomiting, heartburn, hives and hoarseness of voice. The body called leukotrienes. Montelukast works by blocking substances and their relative functions in the body called leukotrienes. Singulair medicines are also used to effectively curb and relieve symptoms of indoor as well as outdoor allergies.