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The signs of recurrence on the skin apparently are related to the production of a large amount of viral particles. Acyclovir is usually taken two to five times a day for up to several months for genital herpes treatment, starting as soon as possible. Zovirax is indicated for the treatment of initial episodes and the management of recurrent episodes of genital herpes. After applying Acyclovir topical. Most pharmacies or supermarkets, are mild antiseptics or moisturisers to help the natural healing process.