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If you are hypersensitive to thyroid hormone. Aside from the treatment of hormone deficiency, Synthroid can also be used to treat or prevent goiter enlarged thyroid gland, which can be caused by hormone imbalances, radiation treatment, surgery, or cancer. Synthroid can interact with a wide variety of medications. Synthroid should be used with caution, when taking Synthroid. Synthroid may cause seizures at the beginning of treatment, although this is rare.