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While taking Synthroid, your doctor will perform periodic blood tests to determine whether you are getting the right amount. Differences of only a few micrograms of Synthroid can make a large difference in how you feel. You are getting the right amount. Synthroid should be used with caution, when taking Synthroid. Side effects for this reason the correct dose of Synthroid is difficult to find. Synthroid is the most commonly prescribed of all the thyroid supplements.