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Lioresal relieves the spasms, cramping, and tightness of muscles caused by medical problems such as multiple sclerosis or certain injuries to the spine. Take all of the prescribed doses. You should not use Bactrim if you are allergic to Sulfamethoxazole or Trimethoprim. Drink plenty of fluids to prevent kidney stones while you are taking Trimethoprim and Sulfamethoxazole.

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